What is the safest antiarrhythmic drug?
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Of all antiarrhythmic agents, dofetilide and amiodarone have been proven safe in patients with heart failure.
Dronedarone was the best tolerated of the antiarrhythmic drugs, with the lowest rates of severe adverse events and a significant reduction in the risk of stroke. It is our practice to use propafenone, flecainide, sotalol, and dronedarone as first-line therapies in patients without structural heart disease (Table 4).